Pythagorio Harbor, sometimes referred to by the locals by its old name Tigani (frying pan), is the best natural harbor in Samos. It provides all-weather shelter although the outer harbor is open to the SE.

One can either moor in the inner harbor or anchor in the outer harbor. In the inner harbor, anchor towards the north end of the quay, avoiding the SW end where most of the day-trip boats moor.

Depths are little more than 5.0 metres anywhere in the harbor, so it should not be necessary to lay out any more than 25 metres of chain, since the holding in mud is excellent. If you do, you make it more likely that someone will lay over your chain (because the inner harbor is always very crowded, especially in summer, fouled anchors are common).

The outer harbor is very safe with the meltemi (the Etesians), however, is not safe with E and SE winds. Two anchors are advisable.