Mytilene is a large and busy harbor and also one of the most polluted in the Aegean, with raw sewage discharged at the very spot where yachts are moored. Recently, however, the harbor has been refurbished, with the bollards and moorings rings repainted and new water and electricity points installed along the quays.

Local yachts moor, sometimes three deep, along the East quay opposite the port police office. Visiting yachts currently moor alongside on either the North or West side of the harbor.

The town of Mytilene itself is a wonderfully alive one. There are terrific pastry stores, and a wonderful market place. The restaurants on the SW of the harbor are popular and have good fish.